What is Dicumarol used to treat?

Dicoumarol is an anticoagulant that acts as a vitamin K antagonist by inhibiting its bioavailability. While high doses of dicoumarol can result in uncontrolled bleeding, it has been utilized in therapeutic doses as an anticoagulant treatment for deep vein thrombosis and other blood clotting disorders.

Is Dicumarol a coumarin?

Dicumarol is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X).

Is Dicoumarol still used?

Identified in 1940, dicoumarol became the prototype of the 4-hydroxycoumarin anticoagulant drug class. Dicoumarol itself, for a short time, was employed as a medicinal anticoagulant drug, but since the mid-1950s has been replaced by its simpler derivative warfarin, and other 4-hydroxycoumarin drugs.

What are side effects of Dicumarol?

COMMON side effects

blurred vision.
a change in vision.
hair loss.
decreased appetite.
gas.

What is the basis of the toxic effect of Dicumarol?

Dicumarol is a competitive inhibitor of vitamin K epoxide reductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.

Is Dicoumarol a warfarin?

Dicoumarol, a symmetrical biscoumarin can be considered as the “parent” of the widely used anticoagulant drug, warfarin. The discovery of dicoumarol’s bioactive properties resulted from an investigation into a mysterious cattle disease in the 1940s.

What is the target of enzyme of Dicoumarol?

Both dicoumarol and warfarin antagonise the blood clotting process through inhibition of vitamin K epoxide reductase (VKOR). This blocks the recycling of vitamin K and prevents the γ-carboxylation of glutamate residues in clotting factors.

What enzyme activates vitamin K?

Within the cell, vitamin K participates in a cyclic process. The vitamin undergoes electron reduction to a reduced form called vitamin K hydroquinone, catalyzed by the enzyme vitamin K epoxide reductase (VKOR).

What is vitamin K also called?

Other name(s): antihemorrhagic factor, menadiol, menadione (vitamin K-3), menaquinone (vitamin K-2), methylphytyl naphthoquinone, phylloquinone (vitamin K-1), phytonadione.

What does dicoumarol stand for?

Dicoumarol. Dicoumarol ( INN) or dicumarol ( USAN) is a naturally occurring anticoagulant that functions as a functional vitamin K depleter (similar to warfarin, a drug that dicoumarol inspired). It is also used in biochemical experiments as an inhibitor of reductases . Dicoumarol is a natural chemical substance…