What is Atgam drug?

Atgam is a polyclonal antibody, or an immune globulin, given as an intravenous (IV, into a vein) infusion. Atgam is used to fight a type of white blood cell called a T-lymphocyte (also called a thymocyte or T-cell). T-lymphocytes are part of your immune system.

What is horse anti-thymocyte globulin?

ANTI-THYMOCYTE IMMUNE GLOBULIN (an tee THI mo cite im MUNE GLOB yoo lin) weakens the body’s immune system. This medicine is used to prevent and to treat kidney transplant rejection. It is also used to treat aplastic anemia.

Can cyclosporine cause low hemoglobin?

Results. Twelve (29%) patients received IST with cyclosporine A (CsA). Eleven (26%) patients became transfusion-dependent. In all patients, a univariate analysis revealed that a low hemoglobin level (p=0.006) and low reticulocyte count (p=0.005) were associated with a high probability of progression.

What is immune globulin infusion?

Immune globulin is a sterile solution made from human plasma. It contains antibodies that protect you against infection from various diseases. Immune globulin intravenous (IGIV, for injection into a vein) is used to treat primary immunodeficiency.

What is Thymo used for?

Thymoglobulin (Thymoglobulin®; Genzyme, Cambridge, Mass., USA) is a purified polyclonal immunoglobulin used for prevention and treatment of acute rejection (AR) following renal transplantation. Thymoglobulin is mostly used for treating vascular, steroid-resistant and antibody-mediated rejection.

How do you use adminadminister Atgam?

Administer ATGAM: via IV infusion over 4 to 6 hours use a 0.2 to 1.0 micron in-line filter monitor blood pressure, pulse, temperature and respiratory rate every 30 minutes for the first hour, then hourly until 3 to 4 hours after the completion of the infusion flush with 100 mL of sodium chloride 0.9%.

How much Atgam should be diluted before infusion?

Do not exceed a concentration of 4 mg of Atgam per mL. Gently rotate or swirl the diluted solution to effect thorough mixing. Allow the diluted Atgam to reach room temperature before infusion.

What is Atgam 50 mg/mL?

Although ATGAM is processed to reduce the level of antibodies that will react to non-T cells, physicians should be prepared for the potential risk of anaphylaxis and monitor patients for signs and symptoms during infusion. Intravenous use only. ATGAM 50 mg/mL concentrate for solution for infusion.

Are there any risks in taking Atgam®?

Allergic reaction may occur despite a negative skin test. There is a potential increased risk for hypersensitivity reaction in those patients previously exposed to ATGAM®. See Administration Details for further information. Serum sickness, an immune-complex mediated reaction, may occur with antithymocyte globulin (ATG) treatment.