What is alpha hydroxy midazolam?
α-Hydroxymidazolam is an active, major metabolite in urine and blood of the benzodiazepine midazolam. Midazolam is sold as Dormicum, Hypnovel®, and Versed as a sedative and treatment for insomnia and seizures.
What is the brand name for midazolam?
Midazolam, sold under the brand name Versed, among others, is a benzodiazepine medication used for anesthesia, procedural sedation, trouble sleeping, and severe agitation….Midazolam.
| Clinical data | |
|---|---|
| Pronunciation | /mɪˈdæzəlæm/ |
| Trade names | Dormicum, Hypnovel, Versed, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a609003 |
Is midazolam hydrophilic or lipophilic?
Midazolam is a benzodiazepine with a unique imidazole ring that allows for both lipophilic and hydrophilic properties. When the pH is less than 4, it is water soluble and the chance of pain at the injection site is lowered. Unlike other benzodiazepines, midazolam becomes lipophilic at a pH greater than 4.
Does midazolam have active metabolites?
Midazolam converts into its active metabolite alpha-1 hydroxy midazolam, which contributes to 10% of drug action. Midazolam metabolism occurs via hepatic CYP450 enzymes and glucuronide conjugation.
What is alpha hydroxy alprazolam used for?
Alpha-hydroxyalprazolam is a metabolite of both alprazolam and adinazolam. Alprazolam (trade name Xanax, available among other generic names) is a short-acting anxiolytic of the benzodiazepine class of psychoactive drugs.
Why is midazolam given at end of life?
Muscle spasm. Parenteral benzodiazepines, such as midazolam, can be used to relieve muscle spasm and spasticity in the last days of life (Table 3).
What is midazolam prescribed for?
Midazolam injection is used before medical procedures and surgery to cause drowsiness, relieve anxiety, and prevent any memory of the event. It is also sometimes given as part of the anesthesia during surgery to produce a loss of consciousness.
Is midazolam a real drug?
What is midazolam? Midazolam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) that is used to help you relax before having a minor surgery, dental work, or other medical procedure. Midazolam may also be used for purposes not listed in this medication guide.
What is Midazolam used to treat?
Midazolam, marketed in English-speaking countries under the trade names Dormicum, Hypnovel, and Versed, is a short-acting drug in the benzodiazepine class developed by Hoffmann-La Roche in the 1970s. The drug is used for treatment of acute seizures, moderate to severe insomnia, and for inducing sedation and amnesia before medical procedures.
What is the pH of midazolam hydrochloride?
Midazolam hydrochloride is reportedly stable at a pH of 3-3.6. McEvoy, G.K. (ed.). American Hospital Formulary Service – Drug Information 92.
Can midazolam be used in renal failure?
Midazolam is a short-acting benzodiazepine routinely used in intensive-care medicine. Conjugates of its main metabolite, alpha-hydroxymidazolam, have been shown to accumulate in renal failure but have not previously been related to the prolonged sedative effects commonly observed in critically ill patients.
What is the osmolality of midazolam hydrochloride injection?
Commercially available midazolam hydrochloride injection occurs as a sterile, clear, colorless to light yellow, aqueous solution of the drug; the injection containing 5 mg of the drug per ml has an osmolality of 385 mOsm/kg.