What is the leading cause of death in renal transplant patients?

What is the leading cause of death in renal transplant patients?

Infection. Infection has been the major cause of death in almost all reports of kidney transplantation,1,4,12,13 both soon and late after transplantation. Multiple organisms are commonly found, and energetic diagnosis and treatment of all infections, especially pneumonia,25 is essential.

Which of the following is the most common cause of death following allogeneic stem cell transplantation?

Toxicity associated with the conditioning regimen, infections, graft-versus-host disease (GvHD) and relapse of the basic disease are the main causes of failure. Depending on patient selection and risk constellation, 10 to >50% of the patients die within 1 year of procedure.

What is the mortality rate of stem cell transplant?

Nonrelapse mortality, measured at 1 year after transplantation, has decreased over time: 29.7% from 1980 through 1989, 24.4% from 1990 through 1999, 14.8% from 2000 through 2009, and 12.2% from 2010 through 2016.

What is transplant related mortality?

Transplant-related mortality (TRM) is defined as death due to causes unrelated to the underlying disease: Patients relapsing are censored as surviving at the time of relapse.

What infectious complication has the highest rate of mortality in post transplant patients?

Infection was the leading cause of death in 53% of patients with a greater proportion occurring in the first year post-transplantation (Figure 1B). Among these, pneumonia and sepsis infection accounted for the majority of infections linked to death.

How many people died during a kidney transplant?

Of the 210,327 patients, 6,774 (3.2%) died within 1 year after receiving a kidney transplant; 756 (11.2%) patients’ cause of death was reported as unknown, while 1,959 (28.9%) patients cause of death was missing (Table 2).

Can stem cell transplants cause death?

Besides the risk of relapse, hematopoietic stem cell transplantation (HSCT) remains associated with significant early and late treatment related mortality (TRM). Infections, toxicity, and (after allogeneic HSCT only), graft-vs. -host disease (GVHD) are the main causes of death.

Has anyone died from stem cells?

Of the neurologists who responded to the survey, one in four had had a patient with complications related to stem cell therapy. Patients who had suffered infections, strokes, spinal tumors, seizures, and even deaths were all reported.

Can bone marrow transplant lead to death?

Some people die as a result of complications from bone marrow transplants. A person who receives a bone marrow transplant may also experience reactions that can follow any medical procedure, including: shortness of breath.

Why does my transplanted kidney hurt?

Pain and tenderness over the kidney transplant commonly occur in the kidney transplant patient. Some etiologies may include hernia, infection, obstruction or pathology in organs adjacent to the transplant.

What happens to the old kidneys after a transplant?

What happens to my old kidneys? In most cases, the diseased kidneys are not removed. There are three conditions that might require your diseased kidneys to be removed: Repeated infection that could spread to the transplanted kidney.

What is the leading cause of death in kidney transplant recipients?

Background: Death with graft function remains an important cause of graft loss among kidney transplant recipients (KTRs). Little is known about the trend of specific causes of death in KTRs in recent years.

Does kidney transplantation reduce mortality?

Using 1996 as the referent year, all-cause as well as cardiovascular mortality declined, whereas mortality due to malignancy did not. For analyses of 10-year mortality, we studied 94,384 patients who received a first kidney transplant from 1996 to 2005.

How many people have had a kidney transplant in the US?

Kidney Transplants. 17,600 kidney transplants were performed in the United States in 2013. Less than one-third of the transplanted kidneys were from living donors in 2013. From 2012 to 2013, there was a 3.1 percent increase in the cumulative number of recipients with a functioning kidney transplant.

Does good risk leukemia transplantation improve survival rates?

An earlier EBMT (European Society for Blood and Marrow Transplantation) analysis of patients with good risk leukemia transplanted between 1980–2001 had shown a significant increase in the 5-year survival rate from the 1980ies to the 1990ies, primarily due to a marked reduction of infectious deaths [ 1 ].