Who manufactures vemurafenib?

Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the U.S. Food and Drug Administration (FDA) approved Zelboraf (vemurafenib) for the treatment of BRAF V600E mutation-positive, inoperable or metastatic melanoma, as determined by an FDA-approved test.

Is Tafinlar FDA approved?

The U.S. Food and Drug Administration approved Tafinlar (dabrafenib) and Mekinist (trametinib), administered together, for the treatment of anaplastic thyroid cancer (ATC) that cannot be removed by surgery or has spread to other parts of the body (metastatic), and has a type of abnormal gene, BRAF V600E (BRAF V600E …

Is Cobimetinib FDA approved?

A new treatment option became available with the FDA approval of cobimetinib in combination with vemurafenib for patients with unresectable or metastatic melanoma and a BRAF V600E or V600K mutation.

How much does Cobimetinib cost?

The cost for Cotellic oral tablet 20 mg is around $7,323 for a supply of 63 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

What is vemurafenib approved for?

IMPLICATIONS FOR PRACTICE: Vemurafenib, an oral monotherapy targeting a mutation in BRAF, is the first U.S. Food and Drug Administration approval for the treatment of Erdheim-Chester disease (ECD). ECD is an extremely rare hematopoietic neoplasm that represents clonal proliferation of myeloid progenitor cells.

What is the target of vemurafenib?

Vemurafenib works to target melanoma cells with the goals of: Slowing the growth or spread of melanoma. Shrinking melanoma tumors.

Is BRAF the same as RAF?

BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is more formally known as serine/threonine-protein kinase B-Raf.

What does PLX4032 mean?

Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy. Nature, 2014, 3;508 (7494):118-22.

Is vemurafenib (PLX4032) a good drug?

For research use only. Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy.

What is the generic name for Zelboraf?

Vemurafenib (INN, marketed as Zelboraf) is a B-Raf enzyme inhibitor developed by Plexxikon (now part of Daiichi-Sankyo) and Genentech for the treatment of late-stage melanoma. The name vemurafenib comes from V600E mutated BRAF inhibition.

How effective is PLX4032 for colon cancer treatment?

PLX4032 is highly effective in the treatment of melanoma, for its ability of inhibiting B-RAF V600E. However, PLX4032 displays limited effect in colon cancer patients that also carrying B-RAF V600E oncoprotein.